DR. ANNA PANCHO YANZA

Building a 3D map of Grem1 progenitors during limb bud development

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Gremlin1 (Grem1), a BMP antagonist is essential for distal limb skeletal development. It is a key node in the self-regulating feedback signalling system that coordinates limb bud outgrowth and patterning. We have generated several mouse models to allow us to study the Grem1-expressing cells and their descendants in limb buds. By combining advanced imaging methods e.g. light sheet microscopy with single cell RNA sequencing we aim to produce a 3D atlas of Grem1-expressing cells to elucidate the contribution of the Grem1 gene to specific cell lineages during limb development.